In this webinar the use case of SentroPAT FO systems in the tablet press feed frame will be presented and discussed.

Shared insights in this webinar are 

• important aspects of implementation
• Pros, Cons and Use Cases
• Effective Approaches and Strategies

Whether you’re a seasoned professional or just curious about the latest advancements in NIR PAT in Pharma OSD (Oral Solid Dosage), this will be worth the time!

Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms, offering benefits like reduced processing time, uniform granule properties, and real-time process control. This study systematically explores the interaction of screw design and processing parameters on mean residence time (MRT) and critical characteristics of granules and tablets, particularly for extended-release (ER) formulations with high polymer content. Using a definitive screening design, the research identifies key operating parameters, highlights challenges, and demonstrates the use of quality-by-design and PAT tools for process optimization and monitoring.

This presentation highlights the critical role of PAT in Pharmaceutical Continuous Manufacturing (PCM) for measuring Critical Quality Attributes (CQA), enabling real-time release, and supporting process control strategies. It discusses the challenges posed by PAT sensors, such as operational complexity and maintenance, and provides guidance on selecting and positioning sensors to optimize process efficiency. Real-world examples demonstrate how current PAT technologies support successful PCM operations, achieving expected Overall Equipment Effectiveness (OEE) and Net Present Value (NPV) while paving the way for future innovations in sensor technology and analytical tools.

This webinar discusses the development and verification of a blending design space model for a mini-batch continuous direct compression line to ensure uniformity. By employing a multivariate process model, the approach establishes boundaries for critical process parameters and material attributes, enabling blend uniformity across mini-batches within the defined design space. This method enhances process understanding, allowing flexibility to accommodate changes in API particle size or fill level while maintaining uniformity.

In a webinar hosted by BioPharma Asia, Tom Van Den Kerkhof (Scientist at Johnson & Johnson) and Sebastian Sowinski (Key Account Manager at Sentronic) shared insights into a control strategy and real-time release testing applied from development to commercial manufacturing.