SentroPAT FO

Diode Array based NIR PAT System

Overview

The SentroPAT FO systems are a trusted cornerstone for Process Analytical Technology (PAT) in the continuous manufacturing of oral solid dosage pharmaceuticals. Renowned for their high performance, long-term stability, and seamless instrument-to-instrument transferability, these systems set the standard for reliability. Developed in close collaboration with leading pharmaceutical partners, SentroPAT FO is purpose-built to meet the rigorous technical and regulatory demands of the industry.

Simultaneously measures the full NIR spectrum in milliseconds.
Provides superior spectroscopic performance.
Offers single-channel or up to 4-channel configurations.
Matches perfectly with SentroProbe diffuse reflectance probes.
Ensures long-term stability with internal wavelength calibration.
Seamlessly integrates with leading PAT management software.

Applications

While the capabilities of the SentroPAT system could benefit a wide range of industries, we have chosen to focus primarily on the pharmaceutical sector, particularly in the manufacturing of oral solid dosage forms. As a result, nine of the world's top ten pharmaceutical companies have chosen Sentronic as a trusted partner for their process analytical needs.

Tablet press feed frame

Sentronic has been involved in the earliest developments of PAT for tablet press feed frame, here in applications back in 2014.

Commercial Scale in Tablet Press Feed Frame

Numerous installations on tablet presses of all major brands are existent today.

SentroProbe MS7 in GEA-Consigma lines

The SentroProbe MS7 was specifically designed to fit the requirements for slow moving powder flow sections as in the GEA PDV and is incorporated in installations for real time release of commercial product.

Blend uniformity in various CDC setups

Sentronic systems are empowering inline control of commercial continuous direct compression lines, here used in combination with the EXPO Process TASO sampling interface.

High Shear Wet Granulation

The improvement of consistency in this unit operatoin using the Sentronic NIR solutions has significant potential and is underutilised today. In comparison to just moisture or particle size analyzers, NIR provides a unique combination of physical and chemical information.

Technical Data

SentroPAT Analyzer

Software Interfaces

Spectrometer Type	Diode Array (256 pixel InGaAs linear array); optionally multiplexed with up to 4 channels
Wavelength Range	1100-2100nm (full specification within 1150 - 2100nm)
Wavelength Accuracy	+-1nm over full specification range
Wavelength Reproducibility	<0.2nm
System noise	Conforms to USP<1856> and EP 2.2.40 requirements
Photometric Linearity	Conforms to USP<1856> and EP 2.2.40 requirements
Embedded PC	Intel Atom based, Windows 10 Professional LTSC
Communication	Ethernet (OPC, TCP/IP, SiPAT)
Housing	GmP friendly (smooth surfaces IP65 / NEMA4)
Dimensions	160 x 220 x 240mm
Operating conditions	10° … 25°C 10% … 90% relative humidity

Chemometric Interfaces	SIMCA, VektorDirektor
OPC-UA	on external PC
OPC-DA	based on dedicated remote server
Integrated to PAT management systems	SIPAT, synTQ, ProaXesS
SDK	A software developer kit is available to directly develop interfaces using TCP/IP protocol

Download data sheet

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Frequent Asked Questions

Learn more about the SentroPat FO and its wide range of applications in pharmaceutical manufacturing. This section provides additional insights and detailed information to help you fully understand the potential and versatility of our cutting-edge sensor technology.

Are there versions with integrated light sources available?

Yes, there are dedicated versions with 5W bulbs and SMA connector available to connect standard probes. Further the version for the SentroProbe DR MS 7 NIR has an integrated light source with a dedicated ferrule connector and 9W.

Is the Measurement with Different Channels Parallel or Sequential?

The measurements are made sequentially. Multiple input channels are switched to one spectrometer module by means of a mutliplexer with piezo based fiber movement.

How Far Away Can the SentroPAT FO Be from it's Process Probe?

For the SentroProbe MS7, the typical fiber optic cable length is 5.5 m. This probe uses a large fiber bundle, and fiber length has a significant impact on cost. However, when using the single-core 400 µm fiber required to connect a SentroProbe DR LS, cable lengths of 25 m or more are easily achievable.

System versions

SentroPAT FO is available in a couple of different version for either single-channel or multi-channel operation, with optional additional temperature control for demanding applications and optional internal light sources, e.g. for use with the SentroProbe MS7.