SentroProbe DR MS7 NIR

Multispot probe for highly increased sample volume

Overview

The SentroProbe MS7 is a multispot process probe designed to take measurements across a chute filled with moving powder in diffuse reflectance mode.

It is commonly paired with the GEA Consigma Light House assembly and used to analyze powder in the slow-moving zones between the outlet of the final blender in a GEA CDC line and the tablet press. When combined with a SentroPAT FO with an internal 9W NIR source, the SentroProbe MS7 can provide vital process information about a continuous manufacturing process.

Seven measurements spots assess large masses of across a moving powder stream
Drift correction of NIR source in connected SentroPAT FO provides outstanding long term stability
Combatible with GEA Consigma Light House assembly, including wash-in-place (WIP) skid, providing in-line probe cleaning and referencing capability
GMP-friendly design

Applications

Combined with a SentroPAT FO system, the SentroProbe MS7 is a powerful tool for monitoring several different types of oral solid dose unit operations. The ability to clean the probe in place when combined with the GEA Consigma light house assembly makes the SentroProbe MS7 an attractive option for dry blends that have a tendency to stick to probe surfaces.

Wet Granulation

The SentroProbe MS7 can be used to assess granule API potency and moisture levels after granule drying and milling and prior to addition to final blend.

Dry granulation

The SentroProbe MS7 can be used to assess granule API potency after granule milling and prior to addition to final blend.

Final Blend Potency

The SentroProbe MS7 can be used to assess final blend API potency immediately prior to tableting. This potency estimate can be used as an input for BU and CU assessment, which may be used as part of a real-time release (RTR) strategy in continuous manufacturing.

Technical Specifications

Optics

Dimensions, Materials of construction

Measurement type	Diffuse Reflectance
Measurement distance	Direct contact with sample material
Spot Size	7 spots each with ca. 5mm
Signal variation between spots	<15% RSD
Fiber cable setup	7 x 24 x 200 μm fibers for illumination 7 x 200 μm separate detection fibers or merged with a fiber taper to 1 x 400 μm FSMA 905 terminated Illumination fiber bundles with a 6 mm ferrule type connector
Fiber cable length and design	Y-shaped cable with a total length of 3 m. Extension up to 5.5 m in 0.5 m steps. Split section approx. 500 mm

Probe materials	Stainless Steel 1.4404 – Sapphire – Stainless Steel 1.4404 Rounded shape
Surface quality of 1.4404	Ra < 0.4 μm
Probe diameter	12mm
Sapphire tube length	60mm
Total shaft length	477mm
Sealing	Use of sealing rings or glue compliant with FDA requirements
Fiber cable protection	Stainless steel tube with silicone made overcoat to ease cleaning

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